Monoclonal antibody to Filarial serpin Wb123 impedes the urokinase plasminogen activator receptor-mediated Alternative activation of macrophages
Prince Upadhyay, Akshay Munjal, Abir Mondal, Gagandeep Singh, Soumyadeep Mukherjee, Mahesh C Kaushik, Puneet K. Gupta, Soumya Pati, Shailja Singh
This study identifies the filarial serpin Wb123 and shows it promotes macrophage alternative activation via uPAR, which is inhibited by the monoclonal antibody MAbG8.
bioRxiv · Feb 5, 2025 · PreprintCell Biology