Cholesterol depletion by MβCD enhances membrane tension, its heterogeneity and affects cellular integrity.
Arikta Biswas, Purba Kashyap, Sanchari Datta, Titas Sengupta, Bidisha Sinha
The paper shows that cholesterol depletion by MβCD increases membrane tension and heterogeneity, leading to increased cell rupture under mechanical stress.
bioRxiv · Feb 12, 2018 · PreprintBiophysics