Bidisha Sinha

The paper shows that intra-cluster receptor density (IRD) regulates TNFR1 signaling, with higher IRD activating and lower IRD impairing signaling.

This study investigates how Myomerger clusters of different sizes influence membrane remodeling during myoblast fusion, showing size-dependent effects on membrane tension and lipid compaction.

This study shows enzyme activity enhances ligand diffusion and receptor-mediated endocytosis by generating mechanical fluctuations in the extracellular matrix.

This study identifies PIEZO1 mechanosensing as a key regulator of ligand-specific TLR9 signaling in human pDCs, showing that CpGA induces IFN production via membrane tension and PIEZO1 activation, while CpGB does not.

This study shows that inhibiting ezrin reduces mechano-protection in cells by altering actin organization and increasing stress fibre formation, which is mitigated by formin inhibition.

The paper investigates how extracellular K+ and Na+ ions differentially regulate TCR signaling by modulating ZAP-70 recruitment, affecting T cell function and development.

This study identifies a non-canonical receptor-like mechanism where CTR1 clusters on the plasma membrane in response to copper, modulating membrane properties to facilitate endocytosis.

This paper maps apico-basal membrane tension gradients in HeLa cells using optical traps and shows that actin contractility and endocytosis are key factors in creating these tension patterns.

This study shows that Cav3 mutations in human dystrophic myotubes impair caveolae function, leading to defective mechanoprotection and aberrant IL6/STAT3 signaling.

The paper shows that cholesterol depletion by MβCD increases membrane tension and heterogeneity, leading to increased cell rupture under mechanical stress.

This study quantifies actomyosin cortex thickness in well-spread cells and finds that reducing contractility or spread area increases cortex thickness and variability.