FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
W. Dai, Z. Wang, G. Wang, Q. A. Wang, R. J. DeBerardinis, L. Jiang
This study shows that FASN-deficiency leads to a cytosol-to-mitochondria citrate flux via IDH1 and CTP, which helps cancer cells resist oxidative stress during detachment.
bioRxiv · Mar 14, 2023Cancer Biology