NOXA/MCL-1 axis determines cell-death decision between apoptosis and pyroptosis and the inflammatory secretome of breast cancer cells treated with anti-mitotics.
A. Dumont, F. Gautier, Q. Batard, C. Guette, F. Guillonneau, M. Campone, P. Juin, S. Barille-Nion
This study shows that the NOXA/MCL-1 axis determines whether breast cancer cells undergo apoptosis or pyroptosis in response to anti-mitotic treatment, and influences the inflammatory secretome.
bioRxiv · Oct 6, 2023 · PreprintCancer Biology