M. Campone

NOXA/MCL-1 axis determines cell-death decision between apoptosis and pyroptosis and the inflammatory secretome of breast cancer cells treated with anti-mitotics.

This study shows that the NOXA/MCL-1 axis determines whether breast cancer cells undergo apoptosis or pyroptosis in response to anti-mitotic treatment, and influences the inflammatory secretome.

Cancer associated fibroblasts mitigate the efficacy of the combination treatment of chemotherapy and BCL-xL targeting in triple negative breast cancer cells

This study shows that BCL-xL promotes chemotherapy resistance in TNBC cells, and CAFs reduce the effectiveness of chemotherapy combined with BCL-xL inhibition.

Targeting of MCL-1 in breast cancer associated fibroblasts reverses their myofibroblastic phenotype and pro-invasive properties

This study shows that targeting MCL-1 in breast cancer-associated fibroblasts reduces their myofibroblastic traits and pro-invasive properties.