Essentiality of CREBBP in EP300 truncated B-cell lymphoma revealed by genome-wide CRISPR-Cas9 screen
M. Nie, B. Zhang, L. Du, W. Ren, J. Joung, X. Ye, J. A. Fuenzalida, X. Shi, D. Liu, K. Wu, F. Zhang, Q. P. Hammarstrom
The paper identifies CREBBP dependency in a DLBCL cell line with EP300 truncation using CRISPR-Cas9 screens and genomic data, suggesting therapeutic targets for heterogeneous cancers.
bioRxiv · Aug 28, 2019 · PreprintCancer Biology