X. Shi

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Analysis of mixtures of birds and insects in weather radar data

This paper develops a method to estimate bird and insect proportions in weather radar data, showing it captures expected migratory patterns in understudied regions.

Genetic Mapping of All Human Paralog Pairs to Characterize Synthetic Lethality and Buffering

This study screens all human paralog pairs to identify synthetic lethal interactions and finds that their strength depends on shared protein interaction networks and cellular context.

Rubisco from two ecotypes of Plantago lanceolata L. that are native to sites differing in atmospheric CO2 levels

The paper examines how magnesium and manganese affect Rubisco activity in two Plantago lanceolata ecotypes adapted to different CO2 environments, finding differences in enzyme kinetics.

Exploring Porphyromonas gingivalis Pathogenesis and Antibody Pool Effect Using a Novel Mouse Reproductive Model

This study uses a mouse model to show that a mixture of antibodies with P. gingivalis infection causes more reproductive damage than infection alone, suggesting an antibody pool effect in pathogenesis.

Coaching ribosome biogenesis from the nuclear periphery

This study shows that nuclear invaginations regulate ribosome biogenesis by contacting nucleoli, with high curvature increasing ribosome production and low curvature reducing it.

Multi-dimensionality of tree communities structure host-parasitoid networks and their phylogenetic composition

The paper examines how tree diversity and canopy cover affect host-parasitoid community composition and interaction networks in a subtropical tree biodiversity experiment.

The 11β-hydroxysteroid dehydrogenase type 1 inhibitor SPI-62 prevents morbidity in a mouse model of Cushing's syndrome

SPI-62, an HSD-1 inhibitor, reduces GC-induced morbidity in a mouse Cushing's syndrome model by improving insulin sensitivity, reducing adiposity, and preventing skeletal myopathy.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

A bispecific antibody-drug conjugate targeting pCAD and CDH17 has antitumor activity and improved tumor specificity

This study develops a bispecific antibody-drug conjugate targeting pCAD and CDH17, showing antitumor activity in dual antigen-expressing tumors but not in single antigen-expressing tumors.

NSm is a critical determinant for bunyavirus transmission between vertebrate and arthropod hosts

This study identifies NSm as a critical protein for bunyavirus transmission between vertebrate and arthropod hosts, showing its necessity for midgut infection and spread.

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

This study shows that protocatechuic acid (PCA) enhances antibiotic efficacy against carbapenem-resistant hypervirulent Klebsiella pneumoniae by inducing oxidative stress through regulation of the EMP-PPP pathway.

The assembly and efflux processes revealed by in situ structures of the ABC-type tripartite pump MacAB-TolC

The paper resolves the in situ structures of the MacAB-TolC efflux pump in E. coli, revealing its assembly process and substrate-driven efflux mechanism.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

Mitochondrial choline import regulates purine nucleotide pools via SLC25A48

This study identifies SLC25A48 as a mitochondrial carrier that mediates choline import, regulating purine nucleotide synthesis and cell survival.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Structural and mechanistic views of enzymatic, heme-dependent nitrogen-nitrogen bond formation

This study investigates the structural and mechanistic basis of N-N bond formation by the heme-dependent enzyme PipS, revealing divergent pathways and a shared nitrenoid intermediate.

Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis

The paper identifies dual regulation of SLC25A39 by AFG3L2 and iron, showing how this controls mitochondrial glutathione homeostasis in neurons.

Lac-Phe mediates the anti-obesity effect of metformin

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

The SAM Domain of EphA2 Inhibits Ligand-Independent Clustering and Activation

This study investigates the role of the SAM domain in EphA2, showing it inhibits ligand-independent clustering and kinase activity in both full-length and intracellular domain constructs.

Depleting glioblastoma cells of very long-chain acyl-CoA synthetase 3 (ACSVL3) produces metabolic alterations in non-lipid pathways

This study shows that knocking out ACSVL3 in glioblastoma cells reduces their malignant traits by altering non-lipid metabolic pathways, including glucose and energy metabolism.

The tRNA Gm18 Methyltransferase TARBP1 Promotes Hepatocellular Carcinoma Progression via Metabolic Reprogramming of Glutamine

This study identifies TARBP1 as a driver gene in hepatocellular carcinoma that promotes tumor progression by methylating tRNA and enhancing glutamine metabolism.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Synergistic effects of multiple pesticides on the flight ability of honey bees (Apis cerana F.)

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

VERY LONG-CHAIN ACYL-CoA SYNTHETASE-3 (ACSVL3) PROMOTES THE MALIGNANT GROWTH BEHAVIOR OF U87 GLIOMA CELLS VIA CHANGES IN CELL CYCLE WITHOUT AFFECTING APOPTOSIS

This study shows that reducing ACSVL3 expression in U87 glioma cells slows their growth and tumor formation in mice by altering the cell cycle without affecting apoptosis.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses

The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

A simple, flexible and high-efficiency western blot analysis for age-related human induced neurons

This paper develops a high-efficiency western blot method using PTSA to analyze age-related human induced neurons and identifies a decline in Parkinson's disease-associated proteins.