Membrane Insertion of Mycobacterium tuberculosis EsxA in Cultured Lung Epithelial Cells
Q. Q. Zhang, J. Aguilera, S. Vazquez Reyes, J. Sun
This study shows that EsxA's cytolytic activity at neutral pH is due to ASB-14 contamination, and EsxA inserts into host membranes in acidic compartments, supporting its role in Mtb virulence.
bioRxiv · Apr 9, 2020 · PreprintBiochemistry