Author

J. Aguilera

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. Sun· 3 shared Q. Zhang· 2 shared S. Vazquez Reyes· 2 shared A. Leithner· 1 shared C. Arico· 1 shared C. B. Karki· 1 shared F. Gaertner· 1 shared H. Ouellet· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

J. Sun

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4 papers

Recent·Most cited

Mechanosensitivity of amoeboid cells crawling in 3D

F. Gaertner, P. Reis-Rodrigues, I. de Vries, M. Hons, J. Aguilera, M. Riedl, A. Leithner, J. Merrin, V. Zheden, W. A. Kaufmann, R. Hauschild, M. Sixt

This study shows how amoeboid cells use WASp-driven actin spikes to push against mechanical loads in 3D environments, enabling efficient migration through dense tissues.

bioRxiv · May 11, 2021Cell Biology

Mycobacterial surface-associated ESX-1 virulence factors play a role in mycobacterial adherence and invasion into lung epithelial cells

Y. Bao, Q. Zhang, L. Wang, J. Aguilera, S. Vazquez Reyes, J. Sun

This study shows EsxA is internalized into host cells and inserts into host membranes, and surface-associated EsxAB enhances mycobacterial adherence and invasion.

bioRxiv · Oct 13, 2020 · PreprintBiochemistry

Membrane Insertion of Mycobacterium tuberculosis EsxA in Cultured Lung Epithelial Cells

Q. Q. Zhang, J. Aguilera, S. Vazquez Reyes, J. Sun

This study shows that EsxA's cytolytic activity at neutral pH is due to ASB-14 contamination, and EsxA inserts into host membranes in acidic compartments, supporting its role in Mtb virulence.

bioRxiv · Apr 9, 2020 · PreprintBiochemistry

Nα-acetylation of EsxA is required for mycobacterial cytosolic translocation and virulence

J. Aguilera, C. B. Karki, L. Li, S. V. Reyes, Q. Zhang, C. Arico, H. Ouellet, J. Sun

This study shows that Nα-acetylation of Thr2 on EsxA is necessary for its dissociation from EsxB and subsequent mycobacterial virulence.

bioRxiv · Jan 8, 2020Biochemistry