YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution
F. Faraji, S. I. Ramirez, L. Clubb, K. Sato, V. Burghi, T. S. Hoang, A. Officer, P. Y. Anguiano Quiroz, W. M. Galloway, Z. Mikulski, K. Medetgul-Ernar, P. Marangoni, K. B. Jones, A. A. Molinolo, K. Kim, , J. S. Gutkind
The paper identifies YAP-driven reprogramming of oral epithelial stem cells into tumor-initiating cells using single-cell multiomics, revealing conserved transcriptional programs linked to poor patient survival.
bioRxiv · Jul 24, 2023Cancer Biology