S. N. Bhatia

Nanobody-targeted conditional antimicrobial therapeutics

This study designs nanobody-targeted conditional antimicrobial therapeutics to deliver therapeutic cargos to bacterial infection sites by enhancing protease activation through proximity-enabled reactivity.

Inhalable point-of-care urinary diagnostic platform

This paper introduces a point-of-care diagnostic platform for lung cancer using inhalable nanosensors that detect tumor-associated proteases through urine analysis.

Spatially regulated protease activity in lymph nodes renders B cell follicles a sanctuary for retention of intact antigens

The paper shows that spatially restricted protease activity in lymph node follicles preserves antigen integrity, leading to stronger GC responses when antigens are targeted to follicular dendritic cells.

Gene signatures and host-parasite interactions revealed by dual single-cell profiling of Plasmodium vivax liver infection

This study uses single-cell profiling to analyze P. vivax liver infection, identifying host and parasite transcriptional signatures and revealing new insights into parasite dormancy and host responses.

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds

This study shows that 3D scaffolds and mitogen stimulation promote cholangiocyte branching in a Notch-dependent manner, offering a model for studying biliary development.

Activatable zymography probes enable in situ localization of protease dysregulation in cancer

This paper introduces activatable zymography probes (AZPs) to detect protease activity in cancer tissues, demonstrating their utility in classifying disease and guiding therapeutic design.

Noninvasive lung cancer detection via pulmonary protease profiling

This study uses activity-based nanosensors to detect early-stage lung cancer in mice with high sensitivity and specificity through urinary readouts of protease activity.