Sphk1-S1P signaling drives blood-brain barrier breakdown after intracerebral hemorrhage via HIF-1α-dependent upregulation of Bsg-MMP-9
Mengzhao Feng, Qi Qin, Kaiyuan Zhang, Min Yu, Fang Wang, Zhihua Li, Junlei Chang, Fuyou Guo
This study identifies Sphk1-S1P signaling as a driver of BBB breakdown after ICH through HIF-1α-dependent upregulation of Bsg-MMP-9, offering a therapeutic target.
bioRxiv · May 6, 2026 · PreprintCell Biology