An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2
Dalton Huey, Eduardo Guadarrama, Jean‐Marc DeKeyser, Carlos G. Vanoye, Christine Q. Simmons, Qianru Li, Emily Kunce Stroup, Zhe Ji, Alfred L. George
This study identifies a uORF in KCNQ2 that represses translation and shows that disrupting it enhances protein expression, with implications for disease and therapy.
Proceedings of the National Academy of Sciences · Aug 18, 2026Peer-reviewedMolecular Biology