Zhe Ji

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2

This study identifies a uORF in KCNQ2 that represses translation and shows that disrupting it enhances protein expression, with implications for disease and therapy.

3'to 5'translation of linear mRNAs?

This study shows linear mRNAs can undergo backward translation in vitro, producing signals comparable to forward translation, and demonstrates the potential of backward translation in synthetic biology.

Delineating yeast cleavage and polyadenylation signals using deep learning

This study uses deep learning to analyze polyadenylation signals in yeast, revealing differences in cleavage heterogeneity and motif configurations between Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anti-cancer drug response

This study uses spike-in normalization in single-cell RNA-seq to reveal dynamic transcriptional changes in cancer cells responding to anti-cancer drugs, identifying gene states and regulatory modules linked to drug efficacy.

Cell type- and stage-specific expression of Otx2 is coordinated by a cohort of transcription factors and multiple cis-regulatory modules in the retina

Regulatory network controlling tumor-promoting inflammation in human cancers

The paper identifies a transcriptional regulatory network involving STAT3, NF-κB, and AP-1 that drives tumor-promoting inflammation in cancers, linking inflammation to immune infiltration and genome instability.