Eduardo Guadarrama

This study identifies a uORF in KCNQ2 that represses translation and shows that disrupting it enhances protein expression, with implications for disease and therapy.

The paper develops classifiers to distinguish functional and trafficking effects of KCNQ1 variants, improving variant interpretation for LQTS and channelopathies.

This study investigates how ADPKD-causing variants in PKD2 affect channel function through structural and electrophysiological analyses.

This study identifies potent PKD2L1 antagonists through high-throughput electrophysiology and computational analysis, revealing a novel binding site and inhibition mechanism.

This study shows that lampreys regenerate their spinal cord equally well after a second transection as after a single one, indicating robust regenerative capacity.