AlaRS-mediated lactylation shields PARP1 from ubiquitination to promote HNSCC progression
Jingjing Zhang, Xinru Meng, Qianni Qin, Qikai Zhou, Ying Lu, Runping Qin, Yujuan Yan, Chang Liu, Siwei Zhang, Xiaoyun Luo, Gen Liu, Yingjie Bian, Zhong‐Wei Zhou, Ji‐Chang Zhou, Jinjun Gao, , Litao Sun
This paper identifies AlaRS as a lactyltransferase that lactylates PARP1, preventing its ubiquitination and promoting HNSCC progression, with a potential therapeutic inhibitor identified.
bioRxiv · May 18, 2026 · PreprintMolecular Biology