Author

PAUL R. SCHIMMEL

Scripps Research InstituteORCID 0000-0002-0448-022XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Alan M. LambowitziD· 1 shared Benjamin J. BlencoweiD· 1 shared Bin MaiD· 1 shared Chang LiuiD· 1 shared Douglas C. WuiD· 1 shared Gen Liu· 1 shared Haissi CuiiD· 1 shared James J. MorescoiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alan M. LambowitzORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 18, 2026

AlaRS-mediated lactylation shields PARP1 from ubiquitination to promote HNSCC progression

Jingjing Zhang, Xinru Meng, Qianni Qin…·Litao Sun

This paper identifies AlaRS as a lactyltransferase that lactylates PARP1, preventing its ubiquitination and promoting HNSCC progression, with a potential therapeutic inhibitor identified.

1 citation

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyNature Cell BiologyPeer-reviewedApr 1, 2023

Arg-tRNA synthetase links inflammatory metabolism to RNA splicing and nuclear trafficking via SRRM2

Haissi Cui, Jolene K. Diedrich, Douglas C. Wu…·PAUL R. SCHIMMEL

The paper shows that arginine depletion during inflammation reduces nuclear ArgRS, which interacts with SRRM2, altering splicing and metabolic outcomes.

38 citations

humanexperimental assay

𝕏 PostBluesky