De novo generation of antibody CDRH3 with a pre-trained generative large language model
Haohuai He, Bing He, Lei Guan, Yu Shan Zhao, Guanxing Chen, Qing-Ge Zhu, Calvin Yu‐Chian Chen, Ting Li, Jianhua Yao
This paper introduces PALM, a pre-trained generative large language model for de novo antibody CDRH3 design, and A2binder for predicting antigen-antibody binding, showing effectiveness against SARS-CoV-2 variants.
bioRxiv · Oct 17, 2023 · PreprintBioinformatics