Author

Lei Guan

National Clinical Research Center for Digestive DiseasesORCID 0009-0006-6293-1232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:large language model· 1 Assay:protein sequence· 1

Frequent Co-Authors

Bing HeiD· 1 shared Calvin Yu‐Chian CheniD· 1 shared Guanxing CheniD· 1 shared Haohuai HeiD· 1 shared Jianhua YaoiD· 1 shared Qing-Ge Zhu· 1 shared Ting Li· 1 shared Yu Shan ZhaoiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperBioinformatics

Bing HeORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintOct 17, 2023

De novo generation of antibody CDRH3 with a pre-trained generative large language model

Haohuai He, Bing He, Lei Guan…·Jianhua Yao

This paper introduces PALM, a pre-trained generative large language model for de novo antibody CDRH3 design, and A2binder for predicting antigen-antibody binding, showing effectiveness against SARS-CoV-2 variants.

1 citation

protein sequencelarge language model

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