Ultra-High-Throughput LC-MS Method for Targeted Protein Degradation Compound Screening Using the Orbitrap Astral Mass Spectrometer
Hanfeng Lin, Yen-Yu Yang, Sudipa Maity, Qingyu Sun, Jin Wang
The paper develops an ultra-high-throughput LC-MS method for TPD compound screening, demonstrating high proteome coverage and quantitation accuracy.
bioRxiv · Oct 18, 2025 · PreprintBiochemistry