Role of YAP in early ectodermal specification anda Huntington's Disease model of human neurulation
Francesco M. Piccolo, Nathaniel R. Kastan, Tomomi Haremaki, Qingyun Tian, Tiago L. Laundos, Riccardo De Santis, Andrew J Beaudoin, Thomas S. Carroll, Ji‐Dung Luo, Ksenia Gnedeva, Fred Etoc, Albert James Hudspeth, Ali H. Brivanlou
This study investigates YAP's role in early ectodermal specification and its link to Huntington's Disease using human neuruloids, finding YAP activation influences ectodermal fate and that reducing YAP activity can partially rescue HD phenotypes.
eLife · Mar 23, 2022Peer-reviewedDevelopmental Biology