Albert James Hudspeth

This study examines sound-evoked mechanical responses in the tokay gecko's basilar papilla, finding untuned rotational motion and proposing anatomical asymmetry as a mechanism for auditory tuning.

This study shows that Vangl2 in different cell types of zebrafish neuromasts contributes to bidirectional hair-bundle polarity and tissue-wide alignment, with distinct roles in hair cells and support cells.

Loss of extracellular matrix-integrin signaling switches off YAP/TEAD and lets prostate adenocarcinoma organoids turn neuroendocrine; LATS inhibition reverses it, and combined YAP, NOTCH and AR inhibition fully reprograms them.

The paper shows Notch signaling drives asymmetry in zebrafish hair cells through a kinase-dependent mechanism, revealing a chiral bias in cell-pair rotations.

The paper identifies col18a1a as a factor guiding axonal defasciculation during zebrafish nerve regeneration, specifically at branching points near neuromasts.

The paper identifies ybx1 as a key regulator promoting rapid hair cell regeneration in zebrafish lateral-line neuromasts by upregulating atoh1a, using the DELAY algorithm to infer gene regulatory networks.

The paper uses optogenetic stimulation and calcium imaging in zebrafish to study how sensory inputs from neuromasts are processed in the brain, revealing nonlinear integration and sparse neuronal representations.

This study identifies Sema7A as a key regulator of neural circuit patterning in zebrafish lateral line by analyzing axonal arborization in wild-type and mutant models.

This paper introduces DELAY, a deep learning method for inferring gene-regulatory networks from single-cell data, showing improved performance over existing methods in identifying causal relationships.

This study investigates YAP's role in early ectodermal specification and its link to Huntington's Disease using human neuruloids, finding YAP activation influences ectodermal fate and that reducing YAP activity can partially rescue HD phenotypes.

The paper develops a method to rapidly stimulate inner-ear hair cells using photonic force, demonstrating its application to vestibular and cochlear hair cells.

The paper identifies a small-molecule inhibitor of Lats kinases that promotes Yap-dependent proliferation in postmitotic mammalian tissues, enabling hair cell regeneration in the inner ear.

The paper shows that tip links in hair bundles can recover rapidly after disruption by restoring calcium ions and re-establishing mechanical contact.

The paper models SOAEs in tokay geckos as coupled oscillators and finds that emissions in one ear influence those in the other through acoustic coupling.

The paper shows Notch1a-mediated lateral inhibition creates a bistable switch for opposite polarity in zebrafish hair cells, confirmed through theoretical and experimental approaches.

The paper maps the connectome of zebrafish neuromasts, revealing specific, redundant, and hierarchical wiring patterns, and identifies Notch signaling as mediating wiring specificity.