PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity.
Patricia Outeda, Qinzhe Wang, Thuy N. Vien, Orhi Esarte Palomero, Louise Faggionato Kimura, Perry Summers, Terry J. Watnick, Feng Qian, Erhu Cao, Paul G. DeCaen
This study investigates how a PKD2 mutation causes primary cilia degeneration and ADPKD by analyzing its structural and functional impact in vitro and in vivo.
bioRxiv · Jun 29, 2026 · PreprintPhysiology