Paul G. DeCaen

This study investigates how a PKD2 mutation causes primary cilia degeneration and ADPKD by analyzing its structural and functional impact in vitro and in vivo.

This study investigates how ADPKD-causing variants in PKD2 affect channel function through structural and electrophysiological analyses.

The paper describes methods to assess neuronal primary cilia electrochemical signaling using electrophysiology and fluorescent sensors to study ion channels and GPCRs.

This study identifies potent PKD2L1 antagonists through high-throughput electrophysiology and computational analysis, revealing a novel binding site and inhibition mechanism.

The paper introduces a synthetic method to assay polycystin ion channel biophysics and characterizes their functional properties.