Terry J. Watnick

This study investigates how a PKD2 mutation causes primary cilia degeneration and ADPKD by analyzing its structural and functional impact in vitro and in vivo.

This study identifies an extra-ciliary role for polycystins in regulating Ezrin and renal tubular morphology through phosphorylation and localization changes.

This study creates a mouse model of SFPQ-TFE3-driven renal tumors and shows it induces lineage plasticity through mTORC1 activation.

This study uses single-nucleus multi-omics to analyze mouse PKD progression, identifying cell-type-specific gene and epigenetic changes and conserved regulatory pathways between mouse and human.

This study uses single-cell multiomic analysis to define cellular complexity in ADPKD, identifying novel transcriptomic and epigenomic features in cystic kidney cells.