Enhancing Prime Editing Efficiency and Flexibility with Tethered and Split pegRNAs
Ying Feng, Siyuan Liu, Qiqin Mo, Xiao Xiao, Pengpeng Liu, Hanhui Ma
This study improves prime editing efficiency and flexibility by introducing tethered and split pegRNAs, achieving 2-4-fold higher mutation rates in cell lines.
Protein & Cell · Jul 15, 2022Peer-reviewedMolecular Biology