Xiao Xiao

This study shows that NSUN2-dependent m5C modifications on influenza A virus RNA are essential for proper viral particle assembly and pathogenicity, suggesting m5C depletion could attenuate IAV strains.

This study improves prime editing efficiency and flexibility by introducing tethered and split pegRNAs, achieving 2-4-fold higher mutation rates in cell lines.

This study uses EpiGo-KRAB to introduce H3K9me3 at specific loci and shows it forms heterochromatin-like domains without widespread gene repression.

The paper develops a CRISPR-based system to image epigenetic modification effects on genome organization in living cells and shows it induces genomic relocation and H3K9me3 decoration.