TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy
George A. Edwards, Caleb A. Wood, Yang He, Quynh Nguyen, Peter J. Kim, Ruben Gomez‐Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al‐Ramahi, Joanna L. Jankowsky
This study shows that TMEM106B deletion worsens tauopathy symptoms in mice, while a coding variant provides protection against cognitive decline and neurodegeneration.
Acta Neuropathologica · Mar 25, 2024Peer-reviewedNeuroscience