Ismael Al‐Ramahi

MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription

This study identifies MeCP2's interaction with the super elongation complex and shows it regulates transcription by modulating RNA polymerase II binding and gene expression.

Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila

This study identifies nervous system requirements for Alzheimer's disease risk genes in Drosophila by analyzing gene function and neurodegeneration.

Systems genetic dissection of Alzheimer's disease brain gene expression networks

This study uses a cross-species approach to identify gene expression networks linked to Alzheimer's disease pathology and neurodegeneration.

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy

This study shows that TMEM106B deletion worsens tauopathy symptoms in mice, while a coding variant provides protection against cognitive decline and neurodegeneration.

Modulation of Karyopherin Levels Attenuates Mutant Ataxin-1-Induced Neurodegeneration

This study shows that increasing KPNA levels reduces mutant Ataxin-1-induced neurodegeneration by retaining it in the cytoplasm and decreasing its nuclear accumulation.

Tau polarizes an aging transcriptional signature to excitatory neurons and glia

The paper uses single-cell RNA-sequencing in Drosophila to show that tau pathology and aging affect different cell types, with tau primarily impacting excitatory neurons and glia.

SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra

SPA-STOCSY is an automated tool for identifying annotated and non-annotated metabolites in NMR spectra, showing high accuracy and efficiency in both synthetic and real data.

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein mediated neurodegeneration

The paper identifies genetic modifiers of alpha-synuclein-mediated neurodegeneration by screening fly homologs of lysosomal storage disorder genes.

Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a Drosophila model of Huntington's Disease

The paper shows that reducing glial genes involved in synaptic function reduces disease pathology and behavioral issues in a Drosophila Huntington's Disease model.