TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis
S. Al Khabouri, R. A. Benson, C. T. Prendergast, J. I. Gray, T. D. Otto, J. M. Brewer, P. Garside
The paper uses TCRβ sequencing to track CD4 T cell clonality and diversity in a mouse model of inflammatory arthritis, finding increased clonality and diversity in lymph nodes over time, with implications for tolerogenic therapy timing.
bioRxiv · Nov 15, 2020Immunology