J. M. Brewer

Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation

This study shows spermidine suppresses dendritic cell activation through eIF5A hypusination and metabolic adaptation, reducing their ability to interact with T cells.

A discovery pipeline for identification and in vivo validation of drugs that alter T cell/ dendritic cell interaction

This paper develops a drug discovery pipeline to identify and validate compounds that modulate T cell/dendritic cell interactions, identifying AS703569 as a novel inhibitor.

Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration

This study shows that timing of antigen administration affects disease outcome in an animal model of inflammatory arthritis, with pre-challenge administration reducing pathology and post-challenge administration exacerbating it.

Streptococcus pneumoniae rapidly translocates from the nasopharynx through the cribriform plate to invade and inflame the dura

This study shows Streptococcus pneumoniae rapidly translocates from the nose through the cribriform plate to the meninges without entering the bloodstream.

TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis

The paper uses TCRβ sequencing to track CD4 T cell clonality and diversity in a mouse model of inflammatory arthritis, finding increased clonality and diversity in lymph nodes over time, with implications for tolerogenic therapy timing.

Developing a xenograft model of human vasculature in the mouse ear pinna

This paper develops a xenograft model of human vasculature in the mouse ear pinna to enable intravital imaging of human blood vessel interactions and parasite infection.