Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy
R. Abukwaik, E. Vera-Siguenza, D. Tennant, F. Spill
This study models the interplay between p53 and XIAP dynamics to predict chemotherapy response, finding that XIAP induction rate, not p53 concentration, determines cell fate.
Journal of Theoretical Biology · Sep 1, 2023Peer-reviewedCancer Biology