Author

D. Tennant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

E. Vera-Siguenza· 2 shared F. Spill· 2 shared R. Abukwaik· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersCancer Biology

E. Vera-Siguenza

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2 papers

Recent·Most cited

P53 Orchestrates Cancer Metabolism: Unveiling Strategies to Reverse the Warburg Effect

R. Abukwaik, E. Vera-Siguenza, D. Tennant, F. Spill

This study develops a mathematical model of p53's role in reversing the Warburg effect by modulating cancer metabolism, showing that p53 activation can restore OXPHOS and that targeting glycolysis may be more effective than targeting SCO2 in p53-mutated cancers.

bioRxiv · Apr 26, 2024Cancer Biology

Interplay of p53 and XIAP protein dynamics orchestrates cell fate in response to chemotherapy

R. Abukwaik, E. Vera-Siguenza, D. Tennant, F. Spill

This study models the interplay between p53 and XIAP dynamics to predict chemotherapy response, finding that XIAP induction rate, not p53 concentration, determines cell fate.

Journal of Theoretical Biology · Sep 1, 2023Peer-reviewedCancer Biology