Author

R. Almaghrabi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

P. Garcia· 3 shared E. Gonzalez· 2 shared M. Raghavan· 2 shared A. Cunningham· 1 shared A. Erdem· 1 shared A. F. Flemban· 1 shared A. Gambus· 1 shared C. Bonifer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

P. Garcia

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

R. Almaghrabi, Y. Alyayhawi, P. Keane, C. R. J. Ward, R. Bayley, C. Sargas, P. Menendez, G. J. Murphy, T. Sobahy, M. A. Baghdadi, A. F. Flemban, S. Kabrah, I. Akerman, M. Raghavan, E. Barragan, , P. Garcia

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

bioRxiv · Jul 24, 2023Cancer Biology

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

N. Vilaplana-Lopera, R. Almaghrabi, G. Papatzikas, V. Cuminetti, E. Gonzalez, M. Jeeves, A. Cunningham, A. Erdem, F. Schnuetgen, M. Raghavan, S. Potluri, J.-B. Cazier, J. J. Schuringa, M. A. Reed, L. Arranz, , P. Garcia

The paper identifies a metabolic crosstalk between AML and stromal cells where AML cells induce stromal cells to secrete acetate for their own energy needs.

bioRxiv · Jan 21, 2021Cell Biology

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells

D. Blakemore, R. Almaghrabi, N. Vilaplana, E. Gonzalez, M. Moya, C. Ward, G. Murphy, A. Gambus, E. Petermann, G. Stewart, P. Garcia

This study shows MYBL2 activates ATM to suppress replication stress in ESCs, with loss of MYBL2 or ATM causing replication fork slowing and increased origin firing.

bioRxiv · Jun 4, 2020Cell Biology