P. Menendez

Integrative single-cell multi-omics of CD19CARpos and CARneg T cells suggest drivers of immunotherapy response in B-cell neoplasias

This study integrates single-cell multi-omics data from CAR-T cells to identify factors influencing immunotherapy response in B-cell neoplasias.

A novel human pluripotent stem cell-based gene activation system identifies IGFBP2 as a mediator in the production of hematopoietic progenitors in vitro

This paper introduces an iCRISPRa system to activate transcription factors in iPSCs, identifying IGFBP2 as critical for hematopoietic progenitor production.

Chromatin activity of IκBα mediates the exit from naïve pluripotency

This study shows that IκBα's chromatin activity, not its NF-κB signaling role, is critical for exiting naïve pluripotency in embryonic stem cells.

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid Leukemia

This study generates and pre-clinically validates CD123-targeted CAR-DOTs for relapsed/refractory AML, showing robust cytotoxicity and long-term persistence with IL-15 support.

A comprehensive single-cell expression atlas of human AML leukemia-initiating cells unravels the contribution of HIF pathway and its therapeutic potential

The paper creates a single-cell atlas of AML leukemia-initiating cells and shows that targeting the HIF pathway enhances chemotherapy effectiveness against these cells.