M. Raghavan

Modeling cardiorespiratory coherence in exercise anticipation

This paper models cardiorespiratory coherence during exercise anticipation, finding that sympathetic modulation, low vagal tone, and respiratory irregularity reduce coherence.

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

Lysosomal Degradation Pathways Target Mutant Calreticulin and the Thrombopoietin Receptor in Myeloproliferative Neoplasms

This study shows that mutant calreticulin induces lysosomal degradation of the thrombopoietin receptor in MPNs, and drug-induced lysosomal activation reduces mutant protein levels and pathogenic effects.

Structural modeling of cytokine-receptor-JAK2 signaling complexes using AlphaFold Multimer

The paper uses AlphaFold Multimer to model cytokine-receptor-JAK2 signaling complexes, revealing activation mechanisms and oncogenic mutation impacts.

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

Mass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing

The paper compares HLA-B44 peptidomes with and without tapasin to show tapasin influences C-terminal tryptophan residues and peptide binding affinity.

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

The paper identifies distinct mutational processes in MHC class I and II genes across primary and metastatic tumors, showing positive selection for mutations disrupting immune interfaces and linking them to immune checkpoint inhibitor response.

Proteome-wide antigenic profiling in Ugandan cohorts identifies associations between age, exposure intensity, and responses to repeat-containing antigens in Plasmodium falciparum

The paper profiles antibody responses to Plasmodium falciparum antigens in Ugandan cohorts, finding that repeat-containing antigens show stronger exposure-dependent responses and shared cross-reactive motifs.

Endo-lysosomal assembly variations among Human Leukocyte Antigen class I (HLA-I) allotypes

This study investigates how HLA-I allotype polymorphisms affect endo-lysosomal assembly and cross-presentation efficiency in monocyte-derived dendritic cells.

A Deep Reinforcement Learning based approach for movement training of neuro-musculoskeletal systems

This paper uses deep reinforcement learning to train a neuro-musculoskeletal model for goal-directed movement, showing convergence to triphasic responses and generalization to untrained movements.

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

The paper identifies a metabolic crosstalk between AML and stromal cells where AML cells induce stromal cells to secrete acetate for their own energy needs.

Mpl is activated by dimers of MPN-linked calreticulin mutants stabilized by disulfide bonds and ionic interactions

This study identifies how mutated calreticulin (CRTDel52) forms dimers stabilized by disulfide bonds and ionic interactions, leading to Mpl activation and cytokine-independent cell proliferation in MPNs.