DNA breaks-mediated cost reveals RNase HI as a new target for selectively eliminating antibiotic resistance
R. Balbontin, N. Frazao, I. Gordo
The paper shows that targeting RNase HI, which degrades R-loops causing DNA breaks, increases the fitness cost of antibiotic resistance and can eliminate resistant bacteria.
bioRxiv · Feb 3, 2020Microbiology