Prodomain-driven enzyme dimerization, a potent pH-dependent autoinhibition mechanism to control Plasmodium Sub1 subtilisin-like activity prior to prime merozoite egress
J.-C. Barale, M. Mariano, B. Anthony, B. Sebastien, R. Bertrand, H. Ahmed, A. M. Pedro
This paper identifies a pH-dependent autoinhibition mechanism in Plasmodium Sub1 protease, where the prodomain drives dimerization at acidic pH to regulate enzyme activity prior to merozoite egress.
bioRxiv · Jul 31, 2023 · PreprintMicrobiology