H. Ahmed

Prodomain-driven enzyme dimerization, a potent pH-dependent autoinhibition mechanism to control Plasmodium Sub1 subtilisin-like activity prior to prime merozoite egress

This paper identifies a pH-dependent autoinhibition mechanism in Plasmodium Sub1 protease, where the prodomain drives dimerization at acidic pH to regulate enzyme activity prior to merozoite egress.

OCT5k: A dataset of multi-disease and multi-graded annotations for retinal layers

The paper introduces OCT5k, a multi-disease and multi-graded annotated dataset for retinal layers to improve automated analysis of OCT scans.

Deep Active Learning for Robust Biomedical Segmentation

This paper introduces a deep active learning framework that reduces annotation needs by 39-54% while improving robustness in medical image segmentation.

O-GlcNAc transferase modulates formation of clathrin-coated pits

This study investigates how O-GlcNAc modification regulates clathrin-coated pit formation and clathrin-mediated endocytosis.

Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS

This study identifies plasma proteins associated with response to chemotherapeutic treatment in oesophageal adenocarcinoma using SWATH-MS and ELISA.

Rest/Stress Myocardial Perfusion Imaging by Positron Emission Tomography with 18F-Flurpiridaz: A Feasibility Study in Mice

This study evaluates the feasibility of rest/stress PET-MPI with 18F-flurpiridaz in mice, finding that myocardial uptake correlates with perfusion parameters and enables CFR estimation.

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

This study uses mathematical models to show that memory CD8 T cells decline following a power law, with division rates stabilizing and death rates declining slowly over decades.

Genomic insight into biogeographic history, divergence, and adaptive potential of G. purpurascens, a forgotten landrace of G. hirsutum

This study analyzes the genomic structure and adaptive potential of G. purpurascens, a landrace of G. hirsutum, to understand its biogeographic history and divergence from modern cultivars.

Using directed attenuation to enhance vaccine immunity

The paper uses mathematical models to show that directed attenuation of viral immune evasion pathways can reduce viral growth without compromising immunity, potentially enhancing vaccine effectiveness.

Tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

The paper identifies Tspan15 as a critical partner of ADAM10, showing their interaction and functional synergy in proteolytic activity.