Oncogenic H-Ras Signaling Differentially Targets Replicative and Specialized DNA Polymerases for Depletion
W.-c. Tsao, R. Buj-gomez, K. Aird, J. Sidorova, K. A. Eckert
This study shows that H-RasG12V overexpression depletes specific DNA polymerases, contributing to replication stress and cell cycle checkpoint enforcement through distinct regulatory mechanisms.
bioRxiv · Jul 1, 2020 · PreprintCancer Biology