Mechanisms of Resistance to CAR-T cell Immunotherapy: Insights from a Mathematical Model
D. S. Santurio, E. A. Paixao, L. R. C. Barros, R. C. Almeida, A. C. Fassoni
The paper develops a mathematical model to study antigen-mediated resistance mechanisms in CAR-T cell therapy, showing how antigen expression levels affect treatment outcomes in hematological cancers.
bioRxiv · May 1, 2023Cancer Biology