L. R. C. Barros

The paper develops a mathematical model to study antigen-mediated resistance mechanisms in CAR-T cell therapy, showing how antigen expression levels affect treatment outcomes in hematological cancers.

This paper develops a three-compartment mathematical model to simulate CAR T-cell immunotherapy outcomes in mice, showing it can represent tumor elimination, equilibrium, and escape based on varying parameters and dosing.

This paper demonstrates that CAR-T cells can be generated using a point-of-care approach without ex vivo activation or expansion, showing equivalent antitumor activity to conventional methods.