Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response.
T. F. Pais, H. Ali, J. M. d. Silva, N. Duarte, R. Neres, C. Chhatbar, R. C. Acurcio, R. C. Guedes, M. C. S. Moraes, B. Costa-Silva, K. Ulrich, C. Penha-Goncalves
This paper identifies STING1 activation by heme from Plasmodium-infected erythrocytes as a key driver of cerebral malaria through type I IFN and CXCL10-mediated inflammation.
bioRxiv · Feb 14, 2022Immunology