C. Penha-Goncalves

Brain endothelial cells exposure to malaria parasites links Type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption and cell metabolic adaptation

This study shows that Type I interferon signaling in brain endothelial cells exposed to malaria parasites enhances antigen presentation and disrupts the endothelial barrier, contributing to cerebral malaria pathology.

Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response.

This paper identifies STING1 activation by heme from Plasmodium-infected erythrocytes as a key driver of cerebral malaria through type I IFN and CXCL10-mediated inflammation.

Amino acids 484 and 494 of SARS-CoV-2 spike are hotspots of immune evasion affecting antibody but not ACE2 binding

Trem-2 modulation of gut microbiota is blunted during hepatotoxic injury and uncoupled from liver repair responses

This study shows that Trem-2 modulates gut microbiota composition but this effect is uncoupled from its protective role in liver repair during hepatotoxic injury.

Trem-2 promotes emergence of restorative macrophages and endothelial cells during recovery from hepatic tissue damage.

This study shows Trem-2 promotes the transition of liver macrophages to restorative phenotypes and influences endothelial cell de-differentiation during liver recovery from injury.