R. C. Klipp

Dynamic landscape of the intracellular termini of acid-sensing ion channel 1a

The paper investigates the conformational dynamics of ASIC1a termini using FRET methods, finding no close interaction at rest and modest movement during desensitization, suggesting a revised model for RIPK1 binding during acidosis.

Structural determinants of Acid-sensing ion channel potentiation by single chain lipids

This study identifies structural features of lipids that modulate ASICs, showing that negatively charged head groups and specific arginine interactions are critical for potentiation.

Insights into the molecular mechanisms underlying the inhibition of acid-sensing ion channel 3 gating by Stomatin

This study identifies two distinct sites on ASIC3 critical for Stomatin binding and regulation, showing that Stomatin affects ASIC3 gating through the transmembrane domain rather than surface expression.