Author

R. C. Locke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Assay:imaging· 4 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:rat· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

M. L. Killian· 5 shared B. D. Stoeckl· 2 shared E. A. Lemmon· 2 shared H. M. Zlotnick· 2 shared J. L. Carey· 2 shared R. L. Mauck· 2 shared S. Gupta· 2 shared A. E. Anderson· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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5 shared papersBioengineering

M. L. Killian

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz

D. L. Jones, R. N. Daniels, X. Jiang, R. C. Locke, M. K. Evans, E. D. Bonnevie, A. Srikumar, M. P. Nijsure, J. D. Boerckel, R. L. Mauck, N. A. Dyment

The paper shows that mechanical tension regulates tendon cell function through Yap/Taz by modulating chromatin accessibility and catabolic gene expression.

bioRxiv · Jul 11, 2022 · PreprintCell Biology

Fabrication and delivery of mechano-activedmicrocapsules containing osteogenic factors in alarge animal model of osteochondral injury

H. M. Zlotnick, R. C. Locke, S. Hemdev, B. D. Stoeckl, S. Gupta, A. P. Peredo, D. R. Steinberg, J. L. Carey, D. Lee, G. R. Dodge, R. L. Mauck

This study develops and tests mechano-active microcapsules containing osteogenic factors in a large animal model to preserve bone structure after osteochondral injury.

bioRxiv · Sep 24, 2021 · PreprintBioengineering

Marked differences in local bone remodeling in response to different marrow stimulation techniques in a large animal

H. M. Zlotnick, R. C. Locke, B. D. Stoeckl, J. M. Patel, S. Gupta, K. D. Browne, J. Koh, J. L. Carey, R. Mauck

This study compares three marrow stimulation techniques in minipigs, finding that needle-puncture best preserves subchondral bone compared to drilling and microfracture.

bioRxiv · Feb 26, 2021Bioengineering

Success Criteria for Preclinical Testing of Cell-Instructive Hydrogels for Tendon Regeneration

R. C. Locke, E. M. Ford, K. G. Silbernagel, A. M. Kloxin, M. L. Killian

This paper establishes in vitro and in situ success criteria for evaluating multi-functional synthetic hydrogels in tendon repair and demonstrates their compliance with these criteria.

bioRxiv · Jul 16, 2020Bioengineering

Mechanics and Differential Healing Outcomes of Small and Large Defect Injuries of the Tendon-Bone Attachment in the Rat Rotator Cuff

A. L. Sullivan, R. C. Locke, R. K. Klink, C. C. Leek, M. L. Killian

This study compares healing outcomes of small and large rotator cuff defects in rats, finding both fail to restore mechanical and structural integrity post-injury.

bioRxiv · Jul 3, 2020Bioengineering

Photobiomodulation Does Not Influence Maturation and Leads to Mild Improvements in Functional Healing of Mouse Achilles Tendons

R. C. Locke, E. A. Lemmon, E. Dudzinski, S. C. Kopa, J. M. Wayne, J. M. Soulas, L. De Taboada, M. L. Killian

This study examines the effects of photobiomodulation (PBM) on mouse Achilles tendon maturation and healing, finding no significant structural changes but mild sex-dependent functional improvements.

bioRxiv · Aug 16, 2019 · PreprintBioengineering

Partial-Width Injuries of the Rat Rotator Cuff Heal with Fibrosis

E. A. Lemmon, R. C. Locke, A. K. Szostek, M. L. Killian

This study examines healing outcomes of partial-width rotator cuff injuries in rats, finding fibrosis and reduced collagen organization without full regeneration.

bioRxiv · Feb 24, 2018Bioengineering

A novel model for the induction of postnatal murine hip deformity

M. L. Killian, P. R. Atkins, R. C. Locke, M. G. James, A. E. Anderson, J. C. Clohisy

This study develops a novel murine model to investigate how postnatal hip instability affects acetabular dysplasia and impingement, finding that severe instability leads to dislocation and morphometric changes.

bioRxiv · Feb 22, 2018Pathology