R. L. Mauck

Microinterfaces in bicontinuous hydrogels guide rapid 3D cell migration

This study develops a bicontinuous hydrogel system that enables rapid 3D cell migration by leveraging microinterfaces, showing mesenchymal behavior across multiple contexts.

Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus

This study uses single cell RNA sequencing to identify distinct subpopulations of notochord-derived nucleus pulposus cells in postnatal mice, revealing developmental stages and molecular signatures associated with extracellular matrix production.

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz

The paper shows that mechanical tension regulates tendon cell function through Yap/Taz by modulating chromatin accessibility and catabolic gene expression.

Developmental Morphogens Direct Human Induced Pluripotent Stem Cells Towards an Annulus Fibrosus-like Cell Phenotype

This study identifies signaling factors that direct human iPSCs to an annulus fibrosus-like phenotype by comparing transcriptomic signatures with mature AF cells.

Fabrication and delivery of mechano-activedmicrocapsules containing osteogenic factors in alarge animal model of osteochondral injury

This study develops and tests mechano-active microcapsules containing osteogenic factors in a large animal model to preserve bone structure after osteochondral injury.

Chemo-Mechanical Cues Modulate Nano-Scale Chromatin Organization in Healthy and Diseased Connective Tissue Cells

This study shows that chemo-mechanical cues influence chromatin organization in connective tissue cells, with disease disrupting this relationship.

Development of A Decellularized Meniscus Matrix-Based Nanofibrous Scaffold for Meniscus Tissue Engineering

This paper develops a nanofibrous scaffold using decellularized meniscus matrix and synthetic polymers to enhance meniscus cell function and matrix production.

Measuring Clinically Relevant Knee Motions With A Self-Calibrated Wearable Sensor

This study validates a low-cost wearable sensor for measuring knee motion during clinical exercises, showing accuracy within 5 degrees for some tasks but larger errors in others.