Characterization of novel competitive inhibitors of P. falciparum cGMP-dependent protein kinase
T. Eck, M. Laureano de Souza, R. R. Y. Bheemanoboina, R. Chakrasali, T. Kreiss, J. J. Siekierka, D. P. Rotella, P. Bhanot, N. M. Goodey
The paper identifies novel isoxazole-based competitive inhibitors of PfPKG with high potency and selectivity over human orthologs.
bioRxiv · Jun 24, 2021Biochemistry