Author

J. J. Siekierka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:plant (other)· 1 Assay:proteomics· 1

Frequent Co-Authors

P. Bhanot· 3 shared T. Eck· 3 shared T. Kreiss· 3 shared A. Roth· 2 shared B. S. Pybus· 2 shared D. J. Colussi· 2 shared D. P. Rotella· 2 shared J. Gordon· 2 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

P. Bhanot

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Discovery of imidazole-based inhibitors of P. falciparum cGMP-dependent protein kinase

R. R. Yadav, M. L. de Souza, M. L. Gonzalez, S. U. Mahmood, T. Eck, T. Kreiss, S. O. Aylor, A. Roth, P. Lee, B. S. Pybus, D. J. Colussi, W. E. Childers, J. Gordon, J. J. Siekierka, P. Bhanot, D. P. Rotella

The paper identifies imidazole-based inhibitors of PfPKG with good potency and low hERG activity against multiple Plasmodium species.

bioRxiv · Nov 5, 2021 · PreprintPharmacology & Toxicology

Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase.

R. R. Y. Bheemanaboina, M. L. Gonzalez, S. U. Mahmood, T. Eck, T. Kreiss, M. L. de Souza, S. O. Aylor, A. Roth, P. Lee, B. S. Pybus, P. Bhanot, D. J. Colussi, W. E. Childers, J. Gordon, J. J. Siekierka, D. Rotella

The paper reports the discovery and optimization of novel PfPKG inhibitors with good potency, low hERG activity, and anti-parasitic activity.

bioRxiv · Aug 24, 2021 · PreprintPharmacology & Toxicology

Characterization of novel competitive inhibitors of P. falciparum cGMP-dependent protein kinase

T. Eck, M. Laureano de Souza, R. R. Y. Bheemanoboina, R. Chakrasali, T. Kreiss, J. J. Siekierka, D. P. Rotella, P. Bhanot, N. M. Goodey

The paper identifies novel isoxazole-based competitive inhibitors of PfPKG with high potency and selectivity over human orthologs.

bioRxiv · Jun 24, 2021Biochemistry